Autism protein may shape neuronal firing patterns
Cells with excess UBE3A, an autism-linked protein, have atypical firing properties that can be corrected by limiting the protein’s levels, according to new research.
Cells with excess UBE3A, an autism-linked protein, have atypical firing properties that can be corrected by limiting the protein’s levels, according to new research.
Two unpublished studies detail improved techniques for delivering gene therapies to the brain.
Our staff picks the stories, podcasts and special reports that stood out from the rest this past year.
The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.
All five participants in a clinical trial of a gene therapy for Angelman syndrome experienced leg weakness, leading sponsors to pause the study.
A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.
Correcting an autism gene mutation in fetal mice lessens some autism-like behaviors after birth.
A new method scans gene expression in live cells and could help scientists study autism genes.
Advances in research and help from families have brought scientists to the brink of an effective therapy for Angelman syndrome.
This year’s list of top papers highlights new dimensions in our understanding of autism genetics and hints at novel treatments.