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Spectrum: Autism Research News

Tag: gene expression

April 2021
Colorful RNA in mouse brain slice

Tissue-swelling method divulges RNA locations, sequences in cells

by  /  28 April 2021

A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.

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Mouse brains carrying CUL3 gene mutation reveal unusually thin cortical tissue.

Neuron ‘skeleton’ may explain impact of autism-linked gene mutation

by  /  16 April 2021

Mutations in CUL3, a gene strongly linked to autism, may cause differences in brain structure by disrupting cytoskeleton proteins, according to a new study.

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A group of six images of fruit fly brains show networks in green and pink.

Poor sleep could be core feature of autism, related conditions

by  /  15 April 2021

Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.

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March 2021

Innate stress response may link maternal infection to autism

by  /  19 March 2021

A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.

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Tiny cortical organoids in petri dish

Year-old organoids echo genetic shifts seen at birth

by  /  8 March 2021

3D cultures of human brain cells kept alive for more than a year undergo transitions in gene activity that resemble those seen in newborns, and may be used to study autism genes in postnatal stages of brain development.

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A digital rendering of a green neuron on black

Brain activity jump-starts autism-linked genes in human neurons

by  /  5 March 2021

Some neurons activate autism-linked genes when they fire, according to a new study.

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Broken protein bridge linked to Rett syndrome traits

by  /  1 March 2021

Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

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February 2021
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

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Singing zebra finches

Autism gene interference silences song memory in birds

by  /  19 February 2021

Muffling expression of an autism-linked gene in a key song-related area of the brain renders young zebra finches unable to learn songs from older birds.

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Genetic variants in protein target sites may contribute to autism

by  /  12 February 2021

Mutations that disrupt binding sites in RNA molecules may play a role in autism and a variety of psychiatric conditions, according to a new study.

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