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Spectrum: Autism Research News

Tag: gene expression

September 2010

Fragile X protein tied to snags in stem cell development

by  /  13 September 2010

The protein missing in fragile X syndrome is necessary for the proper development of neural stem cells — self-renewing cells that can differentiate into more specialized types, including neurons — according to a paper published in the August issue of Human Molecular Genetics.

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August 2010

Fragile X protein linked to potassium channels

by  /  24 August 2010

Mouse models of fragile X syndrome show defects in two kinds of potassium channels — ubiquitous pores that control the flow of electrical current across neurons — in a brain area that processes sound, according to two papers published this summer.

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Simple screens

by  /  10 August 2010

In the not-too-distant future, we may be able to diagnose toddlers with autism using a simple clinical test — based on voice patterns, blood or even urine.

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July 2010

Deep sequencing questions role of imprinted genes in autism

by  /  8 July 2010

The mouse brain has more than 1,300 regions for which the copy from one parent is expressed more often than the one from the other parent, according to two studies published today in Science. These so-called imprinted genes have been proposed to cause some cases of autism, but the researchers say their findings do not support that theory.

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May 2010

Gene expression pattern could pinpoint autism

by  /  25 May 2010

Researchers can reliably identify individuals with autism by looking at the expression pattern of a set of genes in cultured blood cells, according to a poster presented Friday at the IMFAR 2010 conference in Philadelphia.

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April 2010

Undressing oxytocin

by  /  29 April 2010

Scientists have been unable to replicate work showing an association between oxytocin receptor genes and autism.

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Measuring expression

by  /  14 April 2010

To examine protein interactions inside brain cells, scientists typically zero in on one gene at a time. A new method described in today’s Nature simultaneously measures expression of the whole genome.

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Random genetic changes may explain variability in autism

by  /  13 April 2010

Random changes in gene expression can cause genetically identical embryos to develop different traits, according to a study of worms published in Nature. The findings suggest that haphazard movements of molecules could partly explain why autism-associated mutations don’t always cause the same symptoms.

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Rett gene found to control genome structure in neurons

by  /  9 April 2010

The protein that is mutated in Rett syndrome controls the expression of other genes by changing the way DNA packs into a cell, rather than turning genes on or off, according to a study published in Molecular Cell.

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March 2010

Autism and fragile X feature immune signatures

by  /  30 March 2010

Scientists have identified distinct blood signatures of cytokines — proteins that control communication between cells of the immune system — in individuals with fragile X syndrome and autism.

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