Young brains
A large, centralized bank of brain tissue from young people could greatly accelerate autism research. Thanks to a growing interest from nonprofit organizations, the idea is finally gaining momentum.
A large, centralized bank of brain tissue from young people could greatly accelerate autism research. Thanks to a growing interest from nonprofit organizations, the idea is finally gaining momentum.
A technique for detecting gene expression that detects short RNA messages is better suited than traditional methods for analyzing postmortem brain tissue, according to a study published 10 September in BMC Genomics.
Postmortem brains from adults with autism have lower-than-normal levels of the fragile X mental retardation protein, which is missing in individuals with fragile X syndrome.
Stem cells reprogrammed to become neurons can provide a picture of gene expression in neurons that is traditionally available only from brain tissue.
Mice lacking a copy of SHANK3, a gene associated with autism and intellectual disability, show marked improvements in brain signaling after being treated with insulin-like growth factor 1, according to unpublished findings presented Saturday at the International Congress of Human Genetics in Montreal, Canada.
Deleting one copy of TBX1, a gene located on the autism-linked chromosomal region 22q11.2, leads to social and communication deficits in mice.
Mouse pups with a duplication of GTF2I, a gene linked to Williams syndrome and autism, show extreme separation anxiety when separated from their mothers, according to unpublished findings presented Thursday at the International Congress of Human Genetics in Montreal, Canada.
Defects in a signaling pathway that regulates learning and memory could underlie regressive autism, a sudden loss of language or social ability.
The brains of individuals with autism express lower levels of proteins that direct neuronal growth compared with those of controls.
The male offspring of mice subjected to stress during pregnancy can transmit the effects to their own male pups.