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Spectrum: Autism Research News

Tag: gene expression

November 2022
A grid of clocks placed over a colorful gene sequence.

Autism-linked genes clock daily oscillations

by  /  14 November 2022

Rhythmic variations in the genes’ brain expression levels may help explain the sleep problems that often accompany the condition.

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Single astrocyte on black background.

Mouse studies cast astrocytes as stars of sensory perception

by  /  13 November 2022

Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.

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Pink geometric brain against a blue background.

Autism brain signature most pronounced in sensory areas

by  /  2 November 2022

An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.

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October 2022
Image of a synthetic mouse embryo.

Lab-grown ‘embryoids’ offer new window into gene-trait relationships

by  /  26 October 2022

The developmental models have advantages over natural embryos and other synthetic models, such as organoids, but present technical and ethical challenges.

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Jeremy Levin, chief executive officer of Ovid Therapeutics, stands against a bench in a lab.

What next for Angelman?

by  /  20 October 2022

A meeting in Texas reckons with the future of treatment, following two setbacks in 2020.

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A transplanted human organoid labeled with a fluorescent protein in a section of the rat brain.

Human cortical organoids forge functional circuits in rat brains

by  /  12 October 2022

The transplanted cells integrate into living animals’ neural circuitry and influence behavior.

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September 2022
David Geschwind stands in his lab.

Autism researcher Daniel Geschwind nets top National Academies prize

by  /  15 September 2022

The prize recognizes Geschwind’s contributions to our understanding of autism genetics.

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A brown lab mouse perches on a researcher's hand.

Largest-yet fragile X mutation in mice confirms model’s shortcomings

by  /  14 September 2022

A 341-repeat mutation from a person with fragile X does not lead to the syndrome’s traits or function the same way in mice, highlighting a need for different animal models.

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August 2022
Illustration of a cassette tape with the tape replaced by a DNA double helix

‘Retro-Cascorder’ tracks gene-expression timing

by  /  19 August 2022

The new tool may help researchers reconstruct the sequence of biological events that underlie development.

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Conceptual illustration of a DNA double helix

Scans of sundry variant types uncover autism-linked genes

by  /  18 August 2022

Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.

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