Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.
Spectrum: Autism Research News
Tag: gene expression
Such high expression levels may account for the condition’s sex bias, a new preprint suggests — but not everyone agrees with that logic.
A massive update to the MSSNG dataset gives qualified researchers ready access to explore autism’s genetic architecture on a cloud-based platform.
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.