The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.
Spectrum: Autism Research News
Tag: gene expression
The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.
Researchers are increasingly turning to simple animals to learn about autism biology and find leads for new drugs.
Mice exposed to unusually low levels of the placental hormone allopregnanolone in the womb show atypical brain development and autism-like behaviors.
Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.
Spontaneous mutations in parts of the genome that regulate gene EBF3 appear to contribute to autism risk.
The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.
A new spin on the classic CRISPR gene-editing tool can alter the genome’s chemical tags and suppress gene expression for months.