Drug after drug has failed in clinical trials for fragile X syndrome. A new study provides an explanation — a decrease in the drugs’ effectiveness over time — and points to a new strategy that could circumvent this problem.
A single seizure early in life leads to enduring behavioral problems, including diminished sociability, in mice.
New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.
Researcher Randi Hagerman is a big proponent of metformin — a diabetes drug that she is testing in people with fragile X syndrome. In fact, Hagerman takes the drug herself as a preventive measure against cancer.
Watch the complete replay of Mark Bear discussing the latest research on treatments for fragile X syndrome.
Lovastatin, a drug that lowers cholesterol levels, prevents memory and learning problems in a rat model of fragile X syndrome.
About half of boys and men with fragile X syndrome injure themselves — and continue to do so for years.
The relatives of autistic people often have mild traits of the condition. Studying these family members could broaden our understanding of autism.
Finding a mutation linked to autism traits can have life-changing consequences for autistic individuals and their families.
Problems with the minute ‘factories’ that yield energy for cells — the mitochondria — may contribute to learning problems and other traits of fragile X syndrome.