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Spectrum: Autism Research News

Tag: fragile X syndrome

November 2010

Video: Drosophila model of fragile X syndrome bears fruit

by  /  16 November 2010

The fruit fly is a good model for some of the cognitive defects in fragile X syndrome — but researchers sometimes find themselves having to defend their choice.

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October 2010

Speed trap

by  /  13 October 2010

New DNA tests for fragile X syndrome are quick, but also raise ethical questions: they pick up abnormalities in some babies who won’t develop symptoms until adulthood, if at all.

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New tests for fragile X promise routine screening

by  /  11 October 2010

A new wave of genetic tests for fragile X syndrome, the leading cause of inherited mental retardation and the most common genetic cause of autism, may make it possible to routinely screen pregnant women and newborns for the syndrome.

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September 2010

Molecular mechanisms: Fragile X mutation worsens memory loss

by  /  27 September 2010

Genes responsible for Alzheimer’s disease and fragile X syndrome — a form of mental retardation linked to autism — may operate through the same pathway, according to a study published in The Journal of Neuroscience.

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Fragile X protein tied to snags in stem cell development

by  /  13 September 2010

The protein missing in fragile X syndrome is necessary for the proper development of neural stem cells — self-renewing cells that can differentiate into more specialized types, including neurons — according to a paper published in the August issue of Human Molecular Genetics.

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One drug, two birds

by  /  10 September 2010

Seaside Therapeutics has announced results from a phase II clinical trial showing that, in children with autism, STX209 lowers agitation, tantrums, irritability and social withdrawal.

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August 2010

Studies explore amygdala problems in fragile X syndrome

by  /  31 August 2010

The amygdala, a brain region that regulates fear and anxiety, shows abnormal neuronal signaling in a mouse model of fragile X syndrome, according to two studies published this summer. These are the first to explore cellular defects in the region in fragile X.

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Fragile X protein linked to potassium channels

by  /  24 August 2010

Mouse models of fragile X syndrome show defects in two kinds of potassium channels — ubiquitous pores that control the flow of electrical current across neurons — in a brain area that processes sound, according to two papers published this summer.

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Brain’s adaptability begins at single synapse

by  /  10 August 2010

Researchers have uncovered an important molecular piece of a learning mechanism that occurs at the junction between neurons. The findings, which may help understand how the brain is disrupted in disorders such as autism, appear in the 24 June issue of Neuron.

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Fragile X models give clues to stem cell programming

by  /  9 August 2010

Not all stem cells are created equal, a string of new studies suggests: adult cells that are reprogrammed into stem cells carry chemical remnants of the tissue from which they originate, making them distinct from embryonic stem cells. These differences may have important implications for studying fragile X syndrome and other diseases that arise from epigenetic glitches.

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