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Spectrum: Autism Research News

Tag: fragile X syndrome

March 2011

Molecular mechanisms: Autism gene linked to mitochondria

by  /  22 March 2011

Disrupted-in-schizophrenia 1, or DISC1— a protein associated with both autism and schizophrenia — is involved in the transport of mitochondria, the power-houses of the cell, to their correct locations in neurons, according to a study published in February in Molecular Psychiatry.

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First-ever Phelan-McDermid meeting has its Eureka moments

by  /  10 March 2011

The First International Phelan-McDermid Syndrome Symposium, held last week in New York City, brought together scientists and patient advocates to share insights — including a surprising realization about mice missing the SHANK3 gene.

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February 2011

Genetic background alters behavior of fragile X mice

by  /  21 February 2011

Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.

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Left behind

by  /  18 February 2011

High school graduation marks the end of opportunities for social engagement and access to services for many young people with autism.

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Molecular mechanisms: Mice model milder form of fragile X

by  /  16 February 2011

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.

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Fly ‘brainbows’ light up neuronal connections

by  /  9 February 2011

Four years after scientists devised a way to paint individual mouse neurons in different colors, two independent groups have adapted the technique for use in the fruit fly. Both papers, replete with stunning images of fly neurons, appeared 6 February in Nature Methods.

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Molecular mechanisms: Men with fragile X have enlarged brains

by  /  9 February 2011

Men with fragile X syndrome have larger brains overall than controls do, but less matter in regions involved in language and social interaction.

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Future shock

by  /  2 February 2011

As genetic testing becomes routine, people are likely to face difficult choices about parenthood.

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January 2011

New drug rescues function in fragile X syndrome

by  /  20 January 2011

A new drug appears to relieve symptoms of fragile X syndrome by blocking the over-production of a key protein in a subset of people with the disorder, according to a 6 January study in Science Translational Medicine.

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Mind games

by  /  7 January 2011

As more drugs enter clinical trials for fragile X syndrome and soon, hopefully, for autism, the placebo effect will become an important consideration.

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