Tag: fragile X syndrome

October 2019
four panels show mouse neurons showing abnormalities
News

New gene linked to autism, neuron development

by  /  30 October 2019

Mutations in the gene CSDE1 lead to a constellation of developmental delays and conditions, including autism, according to a new study.

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Mitochondrion, coloured transmission electron micrograph (TEM). Mitochondria are a type of organelle found in the cytoplasm of eukaryotic cells. They oxidise sugars and fats to produce energy in a process called respiration. A mitochondrion has two membranes, a smooth outer membrane and a folded inner membrane. The folds of the inner membrane are called cristae, and it is here that the chemical reactions to produce energy take place. Magnification: x62,800 when printed at 10 centimetres wide.
News

Leaky mitochondria may play central role in fragile X syndrome

by  /  23 October 2019

Some traits of fragile X syndrome may be due to problems with mitochondria, the cell’s energy factories.

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News

Mouse study hints at why fragile X drugs fail in trials

by  /  22 October 2019

Drug after drug has failed in clinical trials for fragile X syndrome. A new study provides an explanation — a decrease in the drugs’ effectiveness over time — and points to a new strategy that could circumvent this problem.

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Two mice in a lab test environment
News

Single seizure may have long-lasting effects on brain

by  /  21 October 2019

A single seizure early in life leads to enduring behavioral problems, including diminished sociability, in mice.

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News

Brain ‘organoids’ point to new drug target for fragile X syndrome

by  /  18 October 2019

New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.

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September 2019
Colorful figure with a circle shape (a pill) and an orange X in the background symbolizing Fragile X
Opinion / Q&A

Diabetes drug delivers multiple benefits for people with fragile X syndrome

by  /  17 September 2019

Researcher Randi Hagerman is a big proponent of metformin — a diabetes drug that she is testing in people with fragile X syndrome. In fact, Hagerman takes the drug herself as a preventive measure against cancer.

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August 2019
Portrait of Mark Bear
Multimedia / Webinars

Webinar: Mark Bear discusses fragile X syndrome, from bench to bedside

21 August 2019

Watch the complete replay of Mark Bear discussing the latest research on treatments for fragile X syndrome.

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June 2019
Statin pill rests on blister pack
News

Popular statin shows promise for treating fragile X syndrome

by  /  17 June 2019

Lovastatin, a drug that lowers cholesterol levels, prevents memory and learning problems in a rat model of fragile X syndrome.

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Young man sits alone with his hands over his face
News

Self-injury persists for years in boys with fragile X syndrome

by  /  5 June 2019

About half of boys and men with fragile X syndrome injure themselves — and continue to do so for years.

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May 2019
Man and woman portraits on a "family tree"
Features / Deep Dive

What the ‘broad spectrum’ can teach us about autism

by  /  15 May 2019

The relatives of autistic people often have mild traits of the condition. Studying these family members could broaden our understanding of autism.

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