Tag: FMRP

March 2019
News

Faulty mitochondria may fuel features of fragile X syndrome

by  /  14 March 2019

Problems with the minute ‘factories’ that yield energy for cells — the mitochondria — may contribute to learning problems and other traits of fragile X syndrome.

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January 2019
Features / Deep Dive

Revelando los secretos del síndrome X frágil en Colombia

by  /  31 January 2019

Una remota ciudad colombiana es el hogar del grupo más grande de personas con síndrome de X frágil. Los científicos están aprendiendo de ellos y tratando de ayudar.

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October 2018
Juan Pablo Quintero, Sara Quintero, Soledad Quintero, Rosario Quintero, Yeison Quintero, pose for a group portrait in Ricaurte, Valle del Cauca, on July 28, 2018.
Features / Deep Dive

Unlocking the secrets of fragile X in Colombia

by  /  10 October 2018

A remote Colombian town is home to the world’s largest cluster of people with fragile X syndrome. Scientists are learning from them — and trying to help.

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Illustration of research mice forming the letter "X".
News

Fragile X syndrome’s link to autism, explained

by  /  10 October 2018

Fragile X syndrome is a leading genetic cause of autism. People who have either condition often share certain traits, such as difficulties in social situations.

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September 2018
News

Loss of large proteins underlies fragile X syndrome, study says

by  /  13 September 2018

The protein missing in fragile X syndrome, FMRP, facilitates the production of hundreds of unusually large proteins, some of which are linked to autism.

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Artwork shows a flock of birds flying inside the head of a boy.
Opinion / Viewpoint

How a ‘pacemaker’ for the brain could ease autism traits

by  /  4 September 2018

Looking at the brain as a whole suggests that nudging flawed sets of neurons to collaborate better might alleviate autism traits.

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May 2018
Microscopic image of skin cells
News

Study challenges theory that protein surplus underlies fragile X

by  /  16 May 2018

Many people with fragile X syndrome show average rates of protein production, challenging a long-held assumption about the condition.

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November 2017
Mapping the connections between brain regions in mice can reveal which ones are strengthened by a drug.
News

Mouse imaging study hints at how fragile X drug trial went wrong

by  /  15 November 2017

The drug mavoglurant has no effect on a brain circuit involved in social behavior in a mouse model of fragile X syndrome. That may explain its poor performance in people with the condition.

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magnetic stimulation of human brain
News

Magnetic stimulation bares imbalance of activity in fragile X brains

by  /  14 November 2017

Researchers have used transcranial magnetic stimulation to show that people with fragile X syndrome have weak ‘inhibitory’ signals, those that dampen neuronal activity in the brain.

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white lab rat
News

‘Fragile’ behaviors mar studies of popular autism mouse model

by  /  13 November 2017

Researchers should proceed with caution when studying the behavior of one of the most popular mouse models of autism: the fragile X mouse model.

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