The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.
People with particularly low levels of FMRP, the protein lacking in those with fragile X syndrome, are more likely to also have autism and severe intellectual disability.
Plugging a leaky mitochondrial membrane may help fragile X neurons to mature and function more efficiently.
Mutations in the gene CSDE1 lead to a constellation of developmental delays and conditions, including autism, according to a new study.
Some traits of fragile X syndrome may be due to problems with mitochondria, the cell’s energy factories.
Drug after drug has failed in clinical trials for fragile X syndrome. A new study provides an explanation — a decrease in the drugs’ effectiveness over time — and points to a new strategy that could circumvent this problem.
New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.
Problems with the minute ‘factories’ that yield energy for cells — the mitochondria — may contribute to learning problems and other traits of fragile X syndrome.
Una remota ciudad colombiana es el hogar del grupo más grande de personas con síndrome de X frágil. Los científicos están aprendiendo de ellos y tratando de ayudar.
A remote Colombian town is home to the world’s largest cluster of people with fragile X syndrome. Scientists are learning from them — and trying to help.