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Spectrum: Autism Research News

Tag: FMR1

September 2023
Research image of neurons in mice.

Skewed signaling in striatum may spawn repetitive behaviors

by  /  6 September 2023

Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.

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August 2023
Research images of protein synthesis in mice.

Neuronal deafness to stress may add to protein surplus in fragile X

by  /  29 August 2023

A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.

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July 2023

Unknown isoform adds twist to theory of fragile X origins

by  /  11 July 2023

Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.

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Illustration of a fragile X syndrome chromosome.

New gene-editing method flags fragile X mutation for repair

by  /  5 July 2023

The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.

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May 2023
Research image of neurons and astrocytes.

Astrocytes fuel erratic firing in fragile X neurons

by  /  10 May 2023

A shift in astrocyte secretions may explain the atypical firing patterns of neurons derived from people with fragile X syndrome.

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April 2023
An illustration of a scientist on a stage with a giant pill bottle that has been chopped in half.

Company on brink takes psilocybin to trial for fragile X syndrome

by  /  25 April 2023

The phase 2A trial has its detractors despite positive animal results and is being sponsored by a company that is struggling financially.

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February 2023
Illustration of a sheet of red and white pills, with the red pills arranged in the form of a question mark.

Going on Trial: Orphan drugs; CBD; bumetanide

by  /  28 February 2023

This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.

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an image of a neuron

Neurons struggle to spike without fragile X gene

by  /  17 February 2023

FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.

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January 2023
Research image showing neuronal activity in mice exposed to high-frequency sounds.

Missing mechanism helps solve fragile X protein mystery

by  /  24 January 2023

Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.

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November 2022
Two white mice socialize.

Autism genes converge on disruptions in social brain circuit

by  /  17 November 2022

The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.

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