Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
Spectrum: Autism Research News
Tag: excitatory signaling
The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.
Therapies that target the circuit could boost social activity, new findings suggest.
Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.
The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.
The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Excitatory and inhibitory neurons can derive from the same cellular source in the developing human brain, a new study suggests, overturning a 20-year-old hypothesis. Tomasz Nowakowski discusses the finding’s implications for autism research.
The investigational drug arbaclofen makes autistic people’s brains respond to a visual task more like non-autistic people’s brains do.
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Even partial loss of the gene impairs the mouse brain’s ability to respond to sensory experiences, which may explain why people with SYNGAP1 mutations tend to have learning difficulties and a high pain tolerance.