Tag: excitatory signaling

February 2019
Close up of mouse shows whiskers
News

Four sets of mice call popular autism theory into question

by  /  25 February 2019

An analysis of four mouse models negates certain assumptions underlying the signaling imbalance theory of autism.

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January 2019
Rat neurons
News

Rat model of autism shows unusual brain growth at birth

by  /  30 January 2019

The brains of rats exposed in utero to the seizure drug valproate show a significant increase in brain size around the time of birth.

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December 2018
News

Massive analysis refines map of autism’s genetic roots

by  /  19 December 2018

The largest genetic analysis of postmortem brain tissue to date has yielded maps of when and where genes related to autism are turned on and off throughout life.

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November 2018
Two hands hold two pills, one red and one blue.
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Drug duo delivers brain, behavioral benefits for fragile X syndrome

by  /  8 November 2018

Administering a cholesterol drug alongside an antibiotic eases atypical behavior and restores the signaling balance in the brains of people with fragile X syndrome.

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Artistic interpretation of a neuron in the hippocampus.
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Subset of neurons may underlie brain’s response to experience

by  /  7 November 2018

Experiences may shape the human brain by altering neurons that boost brain activity.

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Chandelier cells send their signals through fibers arranged in vertical columns that are reminiscent of the candles in a chandelier.
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Chandelier cells may sprout few branches in autism brains

by  /  7 November 2018

Specialized neurons called chandelier cells, which dampen brain signals, make unusually few connections in the brains of people with autism.

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Neurons glow green in mice brain.
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Loss of autism gene alters landscape of inhibitory brain signals

by  /  6 November 2018

Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.

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News

Postmortem brain study hints at cell types involved in autism

by  /  5 November 2018

An unprecedented look at gene expression in tens of thousands of brain cells from autistic people suggests important roles in the condition for a neuronal subtype and for microglia.

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Outlines of mice neurons have long branches.
News

Rodent models of autism miss milestone in brain signaling

by  /  4 November 2018

In mice exposed to maternal inflammation in the womb, a key chemical messenger never makes the switch from exciting brain signals to inhibiting them.

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October 2018
News

Study calls into question chemical messenger’s role in autism

by  /  29 October 2018

New results from brain scans of adults with autism are at odds with the popular theory that the condition involves weak brakes on brain activity.

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