Change of heart and mind: Autism’s ties to cardiac defects
Children with congenital heart disease have an increased likelihood of autism. Why?
Children with congenital heart disease have an increased likelihood of autism. Why?
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Nonrandom mating — the propensity for people to partner with others who share their traits — can increase the likelihood of autism or other conditions across generations.
Compared with their non-autistic peers, young autistic girls have a thicker cortex that thins more quickly with age.
If a therapy for autism’s core traits makes it to market, it will likely take one of three forms, the researchers say.
A massive update to the MSSNG dataset gives qualified researchers ready access to explore autism’s genetic architecture on a cloud-based platform.
Within the 16p region of the genome, the two types of variants similarly decrease neuronal gene expression — an effect that may reflect their spatial relationship.
Work in fruit flies has helped Paul decode a neurodevelopmental syndrome in children caused by rare de novo variants in the gene PPFIA3.
The gene, YTHDF2, has not previously been linked to autism.
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.