Copy number variation
Partner selection may amplify rare variants in children
Nonrandom mating — the propensity for people to partner with others who share their traits — can increase the likelihood of autism or other conditions across generations.
Partner selection may amplify rare variants in children
Mitochondria mediate effects of PTEN mutations
Whole-genome sequencing data — which include information about mitochondrial DNA — offer clues to why mutations in the same gene can lead to autism or cancer.
Brain signatures of rare variants hint at cardiovascular risk
People whose brains look like those of people who carry autism-linked copy number variants also share markers of heart health.
Brain signatures of rare variants hint at cardiovascular risk
Common and rare autism-linked variants share functional effects
Within the 16p region of the genome, the two types of variants similarly decrease neuronal gene expression — an effect that may reflect their spatial relationship.
Common and rare autism-linked variants share functional effects
Autistic people at increased genetic risk of sleep problems
Compared with their unaffected siblings and unrelated controls, children with autism harbor more copy number variants in genes that govern the circadian cycle or are associated with insomnia.
Autistic people at increased genetic risk of sleep problems
Autism’s genetic heterogeneity evident in brain connectivity patterns
The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.
Autism’s genetic heterogeneity evident in brain connectivity patterns
‘Dosage sensitivity map’ predicts active ingredients in copy number variants
The catalog of rare copy number variants tied to autism and other conditions could help researchers identify which genes account for the mutations’ effects.
‘Dosage sensitivity map’ predicts active ingredients in copy number variants
Chromosome 22 mutations leave telltale marks on brain development in autistic people
Many brain regions develop differently between people with 22q11.2 duplications and deletions, and those trajectories also vary with a person’s diagnosis.
Chromosome 22 mutations leave telltale marks on brain development in autistic people
Lumping versus splitting with autism-linked variants: A conversation with Vanessa Vogel-Farley and Yssa DeWoody
Researchers have long studied subgroups of people who share genetic variants, but the newly formed ‘CNV Commission’ is also looking at people with shared traits across different neurodevelopmental conditions.
Lumping versus splitting with autism-linked variants: A conversation with Vanessa Vogel-Farley and Yssa DeWoody
Scans of sundry variant types uncover autism-linked genes
Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.
Scans of sundry variant types uncover autism-linked genes
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Inclusivity committee disbands in protest at Canadian neuroscience institute
The majority of an 11-person committee resigned from the group this week following news that a staff position overseeing equity, diversity and inclusion would not be renewed.
Inclusivity committee disbands in protest at Canadian neuroscience institute
The majority of an 11-person committee resigned from the group this week following news that a staff position overseeing equity, diversity and inclusion would not be renewed.
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As a new professor, I was caught off guard by one part of the job: my role as an evaluator.
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What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.
What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.