Common variants
Common genetic variants shape the structure of the cortex
A genome-wide association study lays a foundation for deeper investigation of these variants in neurodevelopmental conditions.
Common genetic variants shape the structure of the cortex
Head size parts autism into two major subtypes
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
Head size parts autism into two major subtypes
Some who lack autism diagnosis carry variants tied to the condition
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Some who lack autism diagnosis carry variants tied to the condition
Genetic background sways effects of autism-linked mutation
Experiments offer clues to why certain mutations are associated with autism in some people and not others.
Genetic background sways effects of autism-linked mutation
Common and rare autism-linked variants share functional effects
Within the 16p region of the genome, the two types of variants similarly decrease neuronal gene expression — an effect that may reflect their spatial relationship.
Common and rare autism-linked variants share functional effects
A mix of common and rare variants shapes autism inheritance patterns
The study also reveals a link between language development and common variants.
A mix of common and rare variants shapes autism inheritance patterns
Genome scan spots common variant differences between autism and ADHD
Common variants in five regions of the genome may determine whether someone has one condition versus the other.
Genome scan spots common variant differences between autism and ADHD
Maternal genetics may confound studies of autism’s link to prenatal factors
Women who carry genetic variants tied to autism have an elevated chance of experiencing pregnancy-related events linked to the condition in their children.
Maternal genetics may confound studies of autism’s link to prenatal factors
Common inherited variants tied to autism show sex bias in families
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Common inherited variants tied to autism show sex bias in families
Spectrum of variants contribute differently to autism traits
Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.
Spectrum of variants contribute differently to autism traits
Explore more from The Transmitter
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.
Neuroscience needs a research-video archive
Video data are enormously useful and growing rapidly, but the field lacks a searchable, shareable way to store them.
Neuroscience needs a research-video archive
Video data are enormously useful and growing rapidly, but the field lacks a searchable, shareable way to store them.