Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
Spectrum: Autism Research News
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Infusions of the hormone oxytocin may make mice that model autism more social by normalizing their brain activity patterns.
Over the past century, scientists have used a variety of animal models to advance their understanding of the developing brain and autism.
Researchers are increasingly turning to simple animals to learn about autism biology and find leads for new drugs.
The investigational drug arbaclofen may right an imbalance between inhibitory and excitatory signaling in the animals’ brains.
Deleting the autism-linked gene CNTNAP2 from mice leads to distinct cellular and electrical changes in the cerebellum, according to two unpublished studies presented virtually today at the 2021 Society for Neuroscience Global Connectome.
A tool that relies on video cameras and machine learning can identify mice that have mutations in a top autism gene by their behaviors. It also detects how a widely used autism drug affects their movements.
Mice missing an autism gene groom themselves more than usual and have altered circadian rhythms after nighttime exposure to light.