An analysis of four mouse models negates certain assumptions underlying the signaling imbalance theory of autism.

A brain region that orchestrates responses to social cues and aids decision-making may be off tempo in autism.

Lattice-like structures that surround neurons may be overly abundant — or scarce — in brain regions of three autism mouse models.

Male monkeys that avoid touching, grooming or playing with others have low brain levels of the hormone vasopressin.

Mice lacking CNTNAP2, a gene strongly linked to autism, are acutely sensitive to pain.

Problems with social interactions stem from faulty wiring of a single circuit spanning distant brain regions, results from three mouse models of autism suggest.