A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.

Mutations in both copies of a gene called ACTL6B lead to autism, epilepsy and intellectual disability.

Rare mutations in a gene called BAZ2B are associated with various conditions of brain development, including autism.

New findings call into question a fundamental assumption about how genes are regulated.

An experimental compound that blocks two enzymes involved in gene expression improves social behavior in young mice.

This year’s list of top papers highlights new dimensions in our understanding of autism genetics and hints at novel treatments.