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Spectrum: Autism Research News

Tag: chromatin

March 2023
A grid of brain scans.

To repair DNA, neurons harness autism-linked proteins

by  /  6 March 2023

The proteins are part of a newly discovered complex that mends genetic damage exclusively in neurons.

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February 2023
Illustration of neurons.

Chromatin remodeling tied to altered splicing in autism model

by  /  7 February 2023

Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.

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November 2022
Three-dimensional structure of cells in the cerebellum.

Flexible genomic architecture undergoes major redesigns during cerebellum development

by  /  13 November 2022

A new atlas reveals how the structural shake-ups within a cell’s genome differ by cell type and brain region over time.

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August 2022
Several strands of DNA with different openings at different points to show different functions for the same gene at different points in time

‘Double duty’ autism-linked genes upend conventional characterizations

by  /  23 August 2022

What these genes do and how they affect autism depends on when in development they’re studied, despite what classic ‘gene ontology’ analyses say.

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July 2022

New resource maps gene expression, regulation in neuron subtypes

by  /  1 July 2022

The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.

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April 2022

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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February 2022

Three autism-linked genes converge on tweaks to cells’ timing

by  /  2 February 2022

Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.

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January 2022
Micrograph of intestinal bacteria.

Infection in pregnant mice ups risk of gut problems in pups

by  /  18 January 2022

Infection during pregnancy can tweak a mouse’s gut microbiome in ways that have lasting effects on her pups’ immune system and increase their chances of gut inflammation, a new study suggests.

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Normal mouse brain (left) vs brain in mouse lacking POGZ gene (right)

Top autism-linked gene boosts DNA accessibility during development

by  /  10 January 2022

Loss of the POGZ gene in mice makes certain genes inaccessible and prevents their expression.

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December 2021
Illustration of DNA helix highlighting the methylation process.

DNA methylation in autism, explained

by  /  13 December 2021

How chemical tags called methyl groups position themselves on genetic sequences may hint at some of the causes of autism.

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