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Spectrum: Autism Research News

Tag: chromatin

April 2022

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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February 2022

Three autism-linked genes converge on tweaks to cells’ timing

by  /  2 February 2022

Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.

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January 2022
Micrograph of intestinal bacteria.

Infection in pregnant mice ups risk of gut problems in pups

by  /  18 January 2022

Infection during pregnancy can tweak a mouse’s gut microbiome in ways that have lasting effects on her pups’ immune system and increase their chances of gut inflammation, a new study suggests.

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Normal mouse brain (left) vs brain in mouse lacking POGZ gene (right)

Top autism-linked gene boosts DNA accessibility during development

by  /  10 January 2022

Loss of the POGZ gene in mice makes certain genes inaccessible and prevents their expression.

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December 2021
Illustration of DNA helix highlighting the methylation process.

DNA methylation in autism, explained

by  /  13 December 2021

How chemical tags called methyl groups position themselves on genetic sequences may hint at some of the causes of autism.

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August 2021
Illustration of brain showing overexcited and underexcited parts of the brain represented by jagged and loose squiggles.

Disruptions to brain’s ‘thermostat’ may underpin autism traits

by  /  18 August 2021

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

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July 2021
Playful clay chromatin strand is not plugged in, there fore, not turned on

Autism’s link to chromatin remodeling, explained

by  /  6 July 2021

Many of the genes strongly linked to autism are involved in the remodeling of chromatin, the complex of DNA and proteins that makes up chromosomes. Scientists are just beginning to understand why.

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April 2021

Loss of CHD8 from cerebellum disrupts movements, not social behaviors

by  /  26 April 2021

Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.

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single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.

Intact-cell sequencing lays bare new view of genome structure

by  /  22 April 2021

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

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A group of six images of fruit fly brains show networks in green and pink.

Poor sleep could be core feature of autism, related conditions

by  /  15 April 2021

Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.

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