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Tag: chromatin

January 2021
Molecular model of histone protein which wraps up DNA strands.
News

New condition hints at structural protein’s role in autism

by  /  22 January 2021

Mutations in genes that encode a histone, which gives structure to chromosomes, can lead to developmental delay and congenital anomalies.

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Neurons show structural changes, seen in black and white.
News

Loss of a top autism gene may alter neuron structure

by  /  12 January 2021

Mutations in the autism-linked gene ASH1L change how neurons grow and develop.

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human and mouse cells.
News / Toolbox

Atlas pair profiles fetal gene expression, regulation in single cells

by  /  7 January 2021

A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.

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lab mice
News

Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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August 2020
Series of micrographs showing neurons with Rett syndrome mutations lacking liquid compartments around DNA.
News

DNA droplets may be key to Rett syndrome, researchers say

by  /  27 August 2020

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

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Proteins binding to RNA, illustration.
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Massive encyclopedia catalogs genome’s regulatory regions

by  /  26 August 2020

The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.

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June 2020
News

Study links gene to inherited form of autism

by  /  25 June 2020

Mutations in both copies of a gene called ACTL6B lead to autism, epilepsy and intellectual disability.

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February 2020
Toddler is balancing with help from mom
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Little-known gene tied to autism, developmental delay

by  /  28 February 2020

Rare mutations in a gene called BAZ2B are associated with various conditions of brain development, including autism.

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September 2019
X chromosome with lots of contrasty texture inside, transparent outside
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Genome structure unlikely to wield major influence on gene expression

by  /  27 September 2019

New findings call into question a fundamental assumption about how genes are regulated.

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February 2019
News

Drugs that modify gene expression show promise for autism

by  /  28 February 2019

An experimental compound that blocks two enzymes involved in gene expression improves social behavior in young mice.

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