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Spectrum: Autism Research News

Tag: CHD8

October 2014

Web of genes may hold clues for autism treatments

by  /  20 October 2014

Many of the genes that have emerged as the strongest autism candidates have turned out to regulate the expression of hundreds, if not thousands, of other genes. Within these networks, scientists are homing in on pathways that underlie autism.

September 2014

Analysis predicts odds of mutations’ link to autism

by  /  11 September 2014

A new method of statistical analysis can predict whether a rare mutation identified in someone with autism has a meaningful association with the disorder or was found only by chance, researchers reported in the September issue of Nature Genetics.

August 2014

Questions for James Noonan: Tracking a candidate gene’s rise

by  /  26 August 2014

Geneticist James Noonan explains how the complex function of CHD8, the leading candidate for autism risk, points to a way to unravel the mechanisms underlying autism.

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July 2014

Cluster of symptoms reveals gene’s link to autism subtype

by  /  3 July 2014

CHD8, a gene that regulates the structure of DNA, is the closest thing so far to an ‘autism gene,’ suggests a study published today in Cell. People with mutations in this gene all have the same cluster of symptoms, including autism.

May 2014

Autism gene may be key to discovering new candidates

by  /  19 May 2014

CHD8, a gene that has emerged as one of the strongest risk factors for autism, regulates the expression of more than half of a set of ‘high-confidence’ risk genes for the disorder. The unpublished data were presented Saturday at the 2014 International Meeting for Autism Research in Atlanta.

March 2014

Emerging importance of chromatin in autism risk

by ,  /  18 March 2014

Sequencing studies over the past few years have made a dramatic and unexpected discovery: Many of the mutations in individuals with autism are in genes that regulate chromatin, which helps package DNA in the cell nucleus, say Gerald Crabtree and Aryaman Shalizi.

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July 2013

Fuzzy network

by  /  5 July 2013

A new network analysis of autism genes, published 11 June in Translational Psychiatry, highlights both the pitfalls and the promise of the approach, says Alan Packer.

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January 2013

Genetics: Autism mutations alter DNA structure

by  /  9 January 2013

A significant proportion of mutations linked to autism alter proteins that regulate gene expression by modifying the structure of DNA, according to a study published 13 November in Molecular Psychiatry.

November 2012
Isolated chromatin

Sequencing study uncovers new candidate genes for autism

by  /  15 November 2012

A new candidate gene for autism, CHD8, may account for up to 0.4 percent of cases of the disorder, according to research published today in Science. CHD8 is one of six genes identified that together may contribute to one percent of autism cases.

May 2012

Chromosome exchanges reveal new autism-related genes

by  /  3 May 2012

Large-scale swapping of genetic material between chromosomes may play an important role in autism, according to a study published 27 April in Cell.

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