Children with mutations either in CHD8 — a top autism gene — or in genes that CHD8 controls share similar characteristics.
Spectrum: Autism Research News
A team of researchers is trialing a fast approach to autism drug development: simultaneously testing candidates in people and in mice.
Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.
The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.
Mice with one inactivated copy of CHD8, a top autism gene, show an unusually high degree of synchrony in neural activity between brain regions.
Boys with autism have smaller heads, are shorter and weigh less at birth than typical children do — but all that changes by age 3.
Integrating human-specific genetic elements into mice may provide a permissive, ‘humanized’ environment for studying autism.
As the list of autism candidate genes grows, some mouse models of the genes turn up in long-forgotten studies.
The male-dominated sex bias in autism is reversed in a related syndrome, a researcher’s gender could influence her study’s outcome, and an award-nominated ad featuring a young man with autism draws criticism.