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Spectrum: Autism Research News

Tag: CHD8

March 2021
Genetic sequencing on computer screen in lab setting.

Online library details traits linked to genetic conditions

by  /  31 March 2021

An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions.

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Top autism-linked gene has divergent effects on brain growth in mice

by  /  25 March 2021

Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.

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Oligodendrocyte shown orange on black in this scanning electron micrograph.

How oligodendrocytes may shape autism

by  /  15 March 2021

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

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February 2021
Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

by  /  23 February 2021

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

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Mutations in frogs point to autism genes’ shared role in neurogenesis

by  /  10 February 2021

Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.

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December 2020
Cells transporting NCKAP1 protein in and out of nucleus

Rare variants tied to neuronal migration, autism traits

by  /  4 December 2020

Many people with mutations in the NCKAP1 gene have autism or autism traits, according to a new study spanning seven countries.

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July 2020
Man working from home office.

INSAR 2020, from home

by  /  31 July 2020

Like so many other events this year, autism’s biggest annual conference — the International Society for Autism Research meeting — was forced to go virtual because of the coronavirus pandemic.

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December 2019
a young girl has her height measured by a woman

Top autism gene tied to unusual skull, skeletal growth

by  /  12 December 2019

People with mutations in CHD8, a top autism gene, tend to be tall and have large heads.

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October 2019

Signaling imbalance in mutant mice supports key autism theory

by  /  19 October 2019

Mice missing a copy of CHD8, a top autism gene, show a signaling imbalance in their brains — a finding in line with a popular hypothesis about autism’s origins.

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August 2019
Spiral DNA against a dark background

Patterns of DNA tags mark candidate genes for autism

by  /  15 August 2019

Children with autism who carry mutations in the chromosomal region 16p11.2 or the gene CHD8 — two of the leading risk factors for autism — show distinct patterns of chemical tags on their DNA.

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