Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Connections between the cerebellum and brain networks do not seem to contribute substantially to the emergence of autism traits.
Deleting the autism-linked gene CNTNAP2 from mice leads to distinct cellular and electrical changes in the cerebellum, according to two unpublished studies presented virtually today at the 2021 Society for Neuroscience Global Connectome.
People with autism or autism traits may be especially vulnerable to brain aging and cognitive decline, two studies suggest.
Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.
Our staff picks the stories, podcasts and special reports that stood out from the rest this past year.
The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.
Like so many other events this year, autism’s biggest annual conference — the International Society for Autism Research meeting — was forced to go virtual because of the coronavirus pandemic.
Long known as the director of movement, the cerebellum may also coordinate social and cognitive abilities, including those central to autism.