Studies find high rate of rare new mutations in autism
Three new studies analyzing genetic data from families in which just one child has autism have found the strongest evidence yet that rare new mutations contribute to the disorder.
Three new studies analyzing genetic data from families in which just one child has autism have found the strongest evidence yet that rare new mutations contribute to the disorder.
A powerful cell that dampens electrical signaling in the brain could help unravel the disrupted brain wiring seen in people with autism, according to results presented yesterday at the Wiring the Brain meeting in Ireland.
Disrupted-in-schizophrenia 1, or DISC1— a protein associated with both autism and schizophrenia — is involved in the transport of mitochondria, the power-houses of the cell, to their correct locations in neurons, according to a study published in February in Molecular Psychiatry.
A new technique documents real-time action in neurons by harnessing the changes in light that take place when they fire.
Using tricks of genetic engineering, researchers in Taiwan have created the first comprehensive map of the myriad neuronal connections in the fruit fly brain. The findings appeared 11 January in Current Biology.
Over the next five years, dozens of researchers funded by the $40 million ‘NIH Human Connectome Project’ will map the circuits of the human brain, tracing neural pathways and learning how different regions work together in synchrony.
Changes in the bodies of neurons may account for communication deficits in the brains of people with autism, according to a study published 3 November in The Journal of Neuroscience.
A study of mice with tuberous sclerosis — a single-gene disorder that is related to autism — suggests that most forms of autism share a common feature: an imbalance of proteins at the synapse, the junction between neurons. The work was presented Monday at the Society for Neuroscience annual meeting in San Diego.
A tumor suppressor best known for its role in colorectal cancer plays a critical role in forming connections between neurons, according to a study in the August 18 issue of the Journal of Neuroscience.
A drug that interferes with a biochemical pathway important in cancer can reverse some brain defects in mouse models of fragile X syndrome, according to a study published 11 August in the Journal of Neuroscience.