Nonrandom mating — the propensity for people to partner with others who share their traits — can increase the likelihood of autism or other conditions across generations.

The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.

Here is a roundup of news and research for the week of 26 June.

Dentist or doctor visits can overwhelm autistic children with sensory sensitivities. Occupational therapy can help, Stein Duker says.

The framework, inspired by the polygenic risk score, considers the cumulative effect of neuronal connections.

This month’s newsletter looks at the early safety data from the first gene therapy trial for Rett syndrome, among other drug development news.

Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.

The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.

Whole-genome sequencing data — which include information about mitochondrial DNA — offer clues to why mutations in the same gene can lead to autism or cancer.

Our feeds this week were full of discussion about a new super-resolution microscopy method and ways to make mouse behavioral experiments more natural.