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Tag: Angelman syndrome

May 2014
Opinion / Viewpoint

Signaling pathways link autism, schizophrenia

by  /  27 May 2014

Autism, schizophrenia and intellectual disability share underlying deficits in pathways that regulate how the brain encodes new experiences, says Jason Shepherd.

3 Comments
March 2014
News

Genetics: MicroRNA may suppress autism gene expression

by  /  25 March 2014

A small fragment of RNA may regulate the expression of RORA, a gene implicated in many autism-related pathways, according to a study published 6 February in Scientific Reports.

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Opinion / Viewpoint

No longer junk: Role of long noncoding RNAs in autism risk

by ,  /  4 March 2014

Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur.

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February 2014
News

Genetics: Chinese population study identifies new autism gene

by  /  11 February 2014

Mutations in TRIM33, a protein that is part of the cell’s cleanup crew, may up the risk for autism, according to a study published 5 November in Molecular Psychiatry.

3 Comments
December 2013
News

Genetics: Prader-Willi syndrome gene is new autism candidate

by  /  10 December 2013

Mutations in a single gene in 15q11.13 — a chromosomal region linked to multiple neurological disorders — may increase the risk of autism, according a study published in November in Nature Genetics.

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November 2013
News

Reactions from SfN 2013

by  /  14 November 2013

Tune in for daily updates and reactions from attendees at the 2013 Society for Neuroscience meeting in San Diego, California.

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October 2013
Opinion / Viewpoint

Length matters: Disease implications for long genes

by  /  22 October 2013

A gene’s length may influence its expression, and this has implications for autism, which tends to be linked to particularly long genes, says Mark Zylka. 

1 Comment
September 2013
News

Molecular mechanisms: Study shows Angelman drug’s actions

by  /  24 September 2013

Researchers have uncovered the mechanism by which a candidate drug for Angelman syndrome activates UBE3A, the gene that is silenced in the syndrome, according to a study published 20 August in the Proceedings of the National Academy of Sciences.

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News

Gene expression in neurons may not match number of copies

by  /  23 September 2013

Neurons derived from individuals who carry extra copies of an autism-linked chromosomal region have gene expression patterns that are unexpectedly similar to those of neurons with deletions of the region. The unpublished findings were presented Thursday at the Dup15q Alliance Scientific Meeting in Sacramento, California.

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Opinion

What does the existence of long genes tell us?

by  /  23 September 2013

Long genes, and their relationship to a class of enzymes that regulate gene expression, raise intriguing questions about the risk for neuropsychiatric disorders.
 

9 Comments