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Spectrum: Autism Research News

Tag: Angelman syndrome

January 2023
Jill Silverman sits at her desk with her dog.

Beyond the bench: Finding solitude with Jill Silverman

by  /  17 January 2023

The people-focused researcher shares her secrets to carving out time for grant writing, creating work-life balance and letting go of unread emails.

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November 2022
Still image showing activity of activity of neurons with genetic mutations in the 15q11-13 chromosomal region.

Single gene insufficient to account for dup15q, Angelman traits

by  /  18 November 2022

UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.

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October 2022
Jeremy Levin, chief executive officer of Ovid Therapeutics, stands against a bench in a lab.

What next for Angelman?

by  /  20 October 2022

A meeting in Texas reckons with the future of treatment, following two setbacks in 2020.

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Photograph of a mouse nesting in a pile of hay.

Scoring mouse behaviors: Q&A with Michael Sidorov

by  /  17 October 2022

A new analysis package enables researchers to distill multiple measures of Angelman syndrome mice into a single ‘severity score.’

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August 2022

Promising preclinical results prompt Angelman therapy trial

by  /  25 August 2022

Roche’s gene therapy drug Rugonersen boosts expression of the protein missing in the syndrome in mice and monkeys, but whether it works in people remains to be seen.

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An Ultragenyx employee removes materials from a lab freezer.

Angelman therapy appears safer in restarted trial

by  /  5 August 2022

Interim results from the previously paused trial suggest that doses of the experimental gene therapy drug GTX-102 are well tolerated in children with the autism-linked condition.

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May 2022
A woman in a white lab coat uses a micropipette

Modified CRISPR tool boosts UBE3A levels in mice

by  /  20 May 2022

A deactivated form of the gene editor restores UBE3A expression in mice and human neurons without cutting the genome. It may hold promise for future Angelman gene therapies.

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April 2022

Open-source algorithm automates common marble-burying assay

by  /  1 April 2022

The machine-learning tool, which automatically counts how many marbles a mouse buries, appears to distinguish between hyperactivity and repetitive behaviors.

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February 2022

Enrichment lessens Angelman-like traits in male mice

by  /  2 February 2022

Model animals don’t develop the usual behavioral and motor problems when reared in an enclosure containing exercise wheels, toys and treats.

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December 2021
Illustration of DNA helix highlighting the methylation process.

DNA methylation in autism, explained

by  /  13 December 2021

How chemical tags called methyl groups position themselves on genetic sequences may hint at some of the causes of autism.

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