Going on Trial rounds up new developments in autism-related drug trials. This month we’re revisiting decade-old data from a trial of arbaclofen for fragile X syndrome and looking into a new implant-based approach to quelling seizures, among other treatment strategies.
Spectrum: Autism Research News
ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.
Loss of the POGZ gene in mice makes certain genes inaccessible and prevents their expression.
Compared with a previous mouse strain, a new model better reflects some of the difficulties that people with a rare autism-related syndrome experience, and may help identify biomarkers of the syndrome.
As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.
Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.
Mutations in two genes linked to autism and intellectual disability boost the immune response and cause synapse dysfunction.
A new autism mouse model carries the same mutation in a gene called ADNP that is seen in autistic people.
Parents of children with rare autism-linked mutations are banding together for support and to join forces with scientists, accelerating the pace of research.