Tag: 16p11.2

June 2018
eight brains with various sections highlighted
News

Chromosome 16 deletion miswires brain in people, mice

by  /  12 June 2018

Mice and people missing a copy of a chromosomal region called 16p11.2 show similar patterns of weak brain connections.

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News

Chromosome 16’s role in brain, behavior varies by sex

by  /  1 June 2018

Female mice may compensate for the loss of a piece of chromosome 16 better than male mice do.

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May 2018
Four brains with different areas colored in red, orange, yellow and black.
News

Brain size varies predictably with loss, gain of DNA segment

by  /  24 May 2018

Missing one copy of a stretch of chromosome 16 leads to an enlarged brain; an extra copy of the region has the opposite effect.

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April 2018
A bundle of nerves connecting the brain’s hemispheres is thinner in mice missing TAOK2 (right) than in controls (left).
News

Gene in autism risk region plays key role in brain development

by  /  4 April 2018

Mice missing TAOK2, a gene in a segment of chromosome 16 linked to autism, have big brains, immature neuronal junctions and asocial behavior.

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March 2018
closeup of a mouse eye
News

Gene on chromosome 16 may be valuable player in autism

by  /  29 March 2018

Deleting one copy of a gene called MVP impairs the brain's ability to adapt to changes in the environment.

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January 2018
Neurons missing a part of chromosome 16 (left) are larger and have more branches than control neurons (middle); neurons with duplications of the region are small and sport short dendrites (right).
News

Lab-grown neurons showcase effects of autism mutations

by  /  15 January 2018

Neurons derived from people with mutations linked to autism display diverse abnormalities that may help explain the origins of these individuals’ features.

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November 2017
Mice lacking KCTD13 have shorter and fewer neuronal branches (middle and right) compared with controls (left).
News

Mouse study questions autism gene’s link to head size

by  /  30 November 2017

Deleting KCTD13, a gene in the autism risk region 16p11.2, has little effect on brain or head size in mice — contradicting results from a 2012 zebrafish study.

1 Comment
black mice exiting hole
News

Learning shows sex bias in mice with mutation tied to autism

by  /  23 November 2017

Male mice with a genetic variant tied to autism may have learning difficulties that females with the variant do not.

1 Comment
Stem cells derived from an individual’s skin can become neurons with her unique genetic makeup.
News

Brain cells spun from skin point to subtypes of autism

by  /  12 November 2017

Neurons derived from people with a syndromic form of autism look and behave differently than do those from people with classic autism.

1 Comment
Two mice sniffing one another.
News

Drug boosts social behavior in mice with deletion tied to autism

by  /  1 November 2017

A drug that has shown promise for treating fragile X syndrome may ease features of another condition associated with autism.

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