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Social motivation, reward and the roots of autism

by , ,  /  1 May 2012

N. Price Ducks in a row: Children with autism may derive less reward from social interactions and more from non-social objects than their typically developing peers.

We believe that these symptoms can be explained by what has been called the ‘social motivation model,’ which posits that social deficits in autism are a consequence of reduced social motivation that starts early in life and has profound developmental consequences, including fewer friendships and social isolation5,6,7,8,9,10

Although social motivation is unlikely to be fully responsible for these unwanted social outcomes, a reduced response to social reward in children with autism could effectively thwart the development of a repertoire of skills that are needed for successful social functioning. The past 30 years of developmental, social and cognitive psychology have demonstrated the importance of numerous skills that when disrupted yield undesirable social outcomes. These include theory of mind, or understanding the thoughts and beliefs of others; joint attention skills and their relationship to communication and language skill development; social-perceptual skills, such as speech intonations that convey meaning and face recognition; and social attention skills for prioritizing relevant components of complex social information. 

Collectively, these skill deficits make it difficult for a person with autism to develop and maintain social relationships, and they describe much of what it means to have autism.

It is not by accident that we describe these symptoms as ‘skilldeficits.’  Adopting a skill-based framework brings into focus the importance of learning processes in the etiology of autism. Although caregivers do engage in explicit social instruction with children, most social learning happens implicitly, from experience. The important question is, why don’t children with autism profit as much from their social learning opportunities as do typically developing children? 

Many processes undoubtedly underlie these deficits in learning. For example, genetic discoveries suggest that neurological processes that mediate learning at the synapse, the junction between neurons, are atypical in individuals with autism. But social learning cannot occur in a vacuum — it requires repeated social learning opportunities. 

The social motivation model suggests that early impairments in the brain’s reward circuitry in children with autism reduce their motivation for social experiences. This lessens their experience with social interactions and the attention they pay to social information, setting in motion developmental processes that ultimately deprive them of adequate social learning opportunities. This, in turn, further disrupts brain and behavioral development.

In other words, when social information is not prioritized, there are profound, cascading effects on learning about — and from — the social world.

Liking vs. wanting:

Social motivation deficits are likely mediated by dysfunction of the mesocorticolimbic reward circuitry, comprising the ventromedial prefrontal cortical-ventral striatal-amygdala brain circuit.

Most people associate reward with something pleasant, such as a piece of chocolate. However, hedonic feelings are only one feature of reward. Reward processes can be parsed into two components, with different circuitry: ‘wanting,’ which refers to incentive striving or motivation, and ‘liking,’ which refers to the pleasurable impact of reward consumption11

Although there are few published studies on reward circuitry in autism, it appears that individuals with the disorder have greater difficulty with ‘wanting’ as opposed to ‘liking.’ Blunted ventral striatal activity during the anticipation as opposed to the experience of reward is the most consistent finding across reward-based functional magnetic resonance imaging studies (fMRI) studies8.

There is an obvious link between ‘liking’ and ‘wanting:’ Experiences that are liked will later be wanted. Experiences that are wanted will also be actively attended to, and we believe that this relationship could explain findings from the eye-tracking literature in autism. In particular, numerous studies of eye gaze in children with autism have shown that they don’t look at social cues as much as do typically developing children2,12.

Interestingly, studies to date suggest that motivation impairments in individuals with autism are the same for different types of reward, such as money and social rewards. However, the experimental methods used for this research are still evolving, preventing us from drawing any firm conclusions. One issue is that most studies use some version of a static photo, such as a smiling face, for a social reward — which is probably hard to get too excited about. Moving forward, more innovative experiments will allow a deeper understanding of the specificity of the reward and motivation deficits in autism and their relationships to skill acquisition.

Push and pull:

Another challenge for the social motivation model will be to understand how motivation deficits in the social domain relate to other features of the disorder that likely are mediated by a common neurocircuitry. These include anxiety and the repetitive behaviors and special interests that are considered core deficits in autism.

By definition, reduced social attention equates to increased attention to other things — strong preoccupations and special interests. Distinguishing reduced social motivation from what can be the enhanced reward value of non-social objects and experiences is critical. There likely will be a dynamic interplay across development between the push and pull of competing motivational factors, and this is a fascinating area for future research.

It is equally important to understand the high prevalence of anxiety — about 50 percent — among individuals with autism. Anxiety is also rooted in the motivation system, but has an aversive influence on behavior. In this regard, social reward and anxiety are likely to be the opposite sides of the same coin, with one propelling behavior as an appetitive force, and the other as an aversive force.

The fact that both aversive and appetitive factors loom large in autism highlights the need for more research on how the disorder impacts the neurobiology of the broader motivation circuitry. It is probably best to think of autism as involving a general impairment in the motivation system, which plays out in unique ways for each individual, such as anxiety, the inability to derive pleasure from typically enjoyable social activities and the incentive value of special interests or repetitive behaviors.

It is a paradox that the field’s most successful interventions are rooted in reinforcement mechanisms that appear to be impaired in individuals with autism. Given the enormous amount of clinical effort devoted to reward-based behavioral interventions, it is alarming that more research is not directed toward the study of reward mechanisms in autism, including studies on why reinforcement-based interventions work well for some individuals but not for others.

Central hypothesis:

In closing, we see the social motivation model as having many significant attributes. First, it creates a theory from a wealth of accumulated empirical data that can guide future research in the form of a set of testable hypotheses. While the developmental literature has produced an abundance of important findings, the field lacks a widely accepted heuristic model to structure future studies. 

Second, it is a developmental model that recognizes that the mechanisms driving the onset of autism are the same ones that sustain it across development. The central hypothesis is that reduced motivation occurs early on in the development of the disorder and that this influences later failures to develop social attention, social-perceptual and social-cognitive skills. One of the most attractive features of the social motivation framework is its ability to account for a broad set of clinical observations and research findings, while not denying the possibility of other contributing factors.  

Third, unlike some psychological models, the social motivation framework is neurobiologically grounded in the reward circuitry of the brain. This provides a tractable way to study the biology in humans and animal models, so that real advances can be made in parallel across disciplines, and so that breakthroughs in basic science can be readily translated to the clinic. 

Finally, the social motivation model may help researchers decide the level at which it is most effective to intervene. If reduced social motivation precedes and drives other developmental skill deficits, it follows that the most effective treatments will be those that target the motivational foundation as opposed to specific social skills that are largely developmental consequences. Enhancing social motivation should open up a set of powerful social learning opportunities by making relevant elements of the social environment more salient and more rewarding.

Robert Schultz is director of the Center for Autism Research at the Children’s Hospital of Philadelphia. Gregor Kohls is a scientist in his laboratory. Coralie Chevallier is a scientist in the Developmental Neuroimaging Laboratory at the Center for Autism Research.

References:

1: Klin A. et al. Arch. Gen. Psychiatry 59, 809-816 (2002) PubMed

2: Sasson N.J. et al. Autism Res. 1, 31-42 (2008) PubMed

3: Leekam S.R. and C.A.H. Ramsden J. Autism Dev. Disord. 36, 185–197 (2006) PubMed

4: Liebal K. et al. J. Autism Dev. Disord. 38, 224–238 (2008) PubMed

5: Chevallier C. et al. Trends Cogn. Sci. 16,231–239 (2012) PubMed

6: Dawson G. et al. Child Dev. 69, 1276–1285 (1998) PubMed

7: Dawson G. et al. Dev. Neuropsychol. 27, 403-424 (2005) PubMed

8: Kohls G. et al. J. Neurodev. Disord. In Press

9: Mundy P. and A.R. Neal Int. Rev. Res. Ment. Retard. 23, 139–168 (2000) Abstract

10: Schultz R.T. Int. J. Dev. Neurosci. 23, 125–141 (2005) PubMed

11: Berridge K.C. and T.E. Robinson Trends Neurosci. 26, 507–513 (2003) PubMed

12: Klin A. et al. Nature 459, 257-261 (2009) PubMed

13: Munson J. et al. J. Int. Neuropsychol. Soc. 14, 956–966 (2008) PubMed

14: Vismara L.A. and S.J. Rogers Annu. Rev. Clin. Psychol. 6, 447–468 (2010) PubMed

15: Helt M. et al. Neuropsychol. Rev. 18, 339–366 (2008) PubMed


8 responses to “Social motivation, reward and the roots of autism”

  1. Zoe Thompson says:

    In the autism interventon Relationship Development Intervention (RDI) we work on supporting parents to help their children re-connect with their internal social motivation. Our work leads to major improvements in joint attention and joint engagement. RDI is a social communication intervention that uses a developmental rather than a behavioural framework that depends on the guided participation relationship (Rogoff) being re-instated between parent and child. Once this is in place, the child begins to give the parent the feedback that parents of typically developing chldren get in the course of natural, instinctive parenting. The parent is then able to use this feedback to gauge the child’s level of competence and to engage in activities that enable the child to develop increasing competence in handling novel information. Because the child is experiencing competence, their internal motivation to engage increases and it is possible to work on many of the developmental steps that they have missed due to their autism.
    You might want to take a look at RDI.

  2. Ruth says:

    Isn’t a capacity for non-social motivation what used to be called “independence”?

  3. Eileen Dillon says:

    My son, 26, is Aspergers. He was always social and wanted to be with other children. However, no one, except druggies, has ever wanted to be with hinm.
    At 26, he hasn’t a single friend and he is miserable. He cannot understand why. He is a mature young man but has trouble with receptive/expressve language and anxiety and depression. He was diagnosed until he was in fourth grade. I started asking when he was a year old but no testing showed any sings of Aspergers. Is he too old to ever have what he wants most? Thank you.

    • susan r says:

      Hi Eileen,
      Is there one young man near you & your son who likes Dungeons & Dragons or another group game like it? Does your son have any inclination toward D&D or a similar activity? Two students I had one year, both with Asperger’s, found each other as friends through D&D and began a group at school that goes on till this day (it’s been 15 years now, and more younger and older members have found them since they graduated, even in our rural area.)
      If not D&D, then perhaps another interest your son has could link him to one or two peaceful, companionable people to share a good time with, maybe even on a weekly basis. His interests make him more interesting to someone else–and vice versa.
      Sometimes people can find each other through websites based around a common hobby, pet, sport, or other activity and build from there to eventual real-time meetings. Focusing on the common interest (instead of on him) takes a lot of the anxiety away.
      Your son’s finding friends would be a boon to you, too…it would allow you to expand your own circle. Do any of your cyber-friends have Aspie sons or daughters, or know of any families in a similar quandary? What do those parents do? Networking lots of different ways. I hope you will both locate a rich vein of multi-age friendship in your local, or cyber-, community.
      I have an idea what you’re going through. My daughter is 27 and, along with other difficulties, cannot speak. But her new iPad is opening doors for her slowly, as she gains skill and can see that what she says will be heard.
      Best wishes to you both.

    • Dewi K.Utama says:

      Dear Eileen Dillon, it is not too late. Where do you live? How if you go to http://www.icdl.com and ask them about services for adult on the autism spectrum.

  4. Brenda Lee Cosse' says:

    Another helpful article! Excited when adults on the Autism Spectrum are addressed with solutions.
    Will share with ‘EnjoyHi5Autism’ networks: http://enjoyhi5autism.blogspot.com; @EnjoyHi5Autism; and https://www.facebook.com/EnjoyHi5Autism

  5. Ettina says:

    One thought I had – Leo Kanner’s original description suggested that some autistic kids might become more socially motivated with age. However, if a child spends their early years uninterested in social interaction, they may fail to develop certain social skills during a critical period (just like kids born with surgically-repairable blindness typically show visual processing issues after their vision is restored).

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