To find the pathogenic mutations in complex disorders such as autism, researchers may need to conduct sophisticated analyses of the genetic functions that are disrupted, says geneticist Aravinda Chakravarti.
Spectrum: Autism Research News
Expert opinions on trends and controversies in autism research.
Studies of autism prevalence should screen a representative sample of all individuals in the population, even those with no indications of the disorder, says epidemiologist Young-Shin Kim.
Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new hypothesis, several new findings have strengthened the evidence for it considerably.
Maternal antibodies that attack fetal brain proteins could underlie some cases of autism, says immunologist Betty Diamond.
Autism and attention deficit hyperactivity disorder show genetic and neurobiological overlap, which may provide clues to the origin of both disorders, says Joel Nigg.
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