Studying the cellular and molecular mechanisms that underlie autism is crucial to advancing our understanding of the disorder, says neuroscientist Eric Kandel.
Expert opinions on trends and controversies in autism research.
The etiology of autism may be best understood as an impairment of neuronal circuits, specifically interneurons that dampen signals in the brain, says neuroscientist Gordon Fishell.
Over the past 30 years, autism research pioneer Fred Volkmar says he has learned that researchers should be humble when assigning meaning to autism behavior, and seek to translate their findings into useful applications.
Individuals who have autism and dysmorphology comprise a distinct subgroup within the disorder, says geneticist Judith Miles.
Charcot-Marie-Tooth disease and autism are both associated with alterations in the number of copies of certain genetic regions, mutations in multiple candidate genes and with both inherited and spontaneous mutations, notes human geneticist James Lupski.
Including more females in autism research studies will aid the search for genetic and environmental susceptibility factors for the disorder, says genetic psychiatrist Lauren Weiss.