To focus the search for environmental risk factors in autism, we should look for chemicals that influence the molecular pathways associated with candidate risk genes, say Pamela Lein and Marianna Stamou.
Expert opinions on trends and controversies in autism research.
In 2003, John Rubenstein and Michael Merzenich first described the theory, now popular in autism, that the disorder reflects an imbalance between excitation and inhibition in the brain. Takao K. Hensch and Parizad M. Bilimoria review the paper and its impact on the field.
Helen McCabe’s analysis of autism interventions in China underscores the need to provide information on evidence-based treatments to parents and teachers.
Mitochondrial deficits may account for the range of symptoms and neurological deficits seen in autism and explain why it preferentially affects boys, says Douglas Wallace.