Viewpoint

Steve Warren co-discovered the genetic mechanism that underpins fragile X syndrome and was a generous, inspiring mentor to many.

Studies of autism subtypes rarely validate their results, and this has led to a proliferation of autism subtypes of questionable utility. But reliable subtyping can help improve the prognosis for and care of autistic people.

Despite the growing interest in alexithymia in autism research, the tools commonly used to measure this trait may not work reliably in autistic populations. A new scoring method fills that gap.

Integrating genetic analyses into studies of babies’ brain development could help us understand how autism-related genes contribute to autism traits.

When probing the circuits underlying social behavior in animal models of autism, researchers should consider potentially confounding variables, use multiple behavioral assays and report results in a descriptive and unbiased manner.

Zemi Yenus was the mother of a child with autism, founder of Ethiopia’s first school for autistic children and a tireless advocate for autism awareness and research in Africa.

The recognition of autism independently at different times and across different cultures shows the condition has clear boundaries, despite considerable heterogeneity.

Anyone who uses multiple animals from a small number of litters to increase sample size is making a serious mistake. The similarities within individual litters will heavily skew the results.

There is not yet a single example of a gene that, when mutated, increases the likelihood of autism but not of other neurodevelopmental conditions, including intellectual disability.

To guard against hype, scientists studying oxytocin’s role in autism and its potential as a treatment need to embrace robust theories, rigorous delivery methods and reproducible research practices.