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Researchers make neurons from blood cells

by  /  28 March 2012
THIS ARTICLE IS MORE THAN FIVE YEARS OLD

This article is more than five years old. Autism research - and science in general - is constantly evolving, so older articles may contain information or theories that have been reevaluated since their original publication date.

Blood drive: Researchers can make stem cells from blood cells, avoiding the need for painful skin biopsies.

Researchers have generated neurons from the blood cells of individuals with autism, according to a study published 7 March in Neuroscience Letters1.

Studies published in the past two years have shown that a similar technique can be used to reprogram blood cells2,3,4. Blood offers some advantages over fibroblasts: Having blood drawn is less painful than a skin biopsy; it is also a routine part of research studies including individuals with autism. However, these studies did not collect blood cells from individuals with a disorder, or develop them into human-specific cell types.

In the new work, researchers converted blood cells from three men diagnosed with autism into embryonic stem cells. They then coaxed these immature cells to develop into neurons, in particular, neurons expressing gamma-aminobutyric acid, or GABA, a chemical messenger that dampens signals in the brain.

Between 48 and 77 percent of the cells generated from the cell lines expressed a number of genes specific to GABA neurons, the study found, including GAD67 and VGAT.

In the past few years, research has suggested that deficits in GABA neurons play a critical role in mechanisms underlying autism. Having a system in which to study alterations in GABA neurons derived directly from a large number of individuals with autism could provide clues into the mechanisms underlying the disorder.

References:

1: Derosa B.A. et al. Neurosci. Lett. Epub ahead of print (2012) PubMed

2: Chou B.K. et al. Cell Res. 21, 518-529 (2011) PubMed

3: Loh Y.H. et al. Cell Stem Cell 7, 15-19 (2010) PubMed

4: Staerk J. et al. Cell Stem Cell 7, 20-24 (2010) PubMed