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Emerging tools and techniques that may advance autism research.

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February 2021
cells in a mouse brain show the mutations in green.

Molecular switch marks mosaic mutations in mice

by  /  11 February 2021

A new tool enables researchers to create mosaic mutations in only some cells and then accurately identify which cells are affected.

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white mouse looking at something out of frame

New tool captures dynamic changes in decision-making

by  /  4 February 2021

A new open-source software package makes it possible to model changes in human and animal behavior over the course of an experiment.

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January 2021

Method may improve safety of gene therapies targeting the brain

by  /  28 January 2021

A new approach for delivering gene therapy to the brain reduces nerve damage in primates and could help make gene therapies for conditions related to autism safer.

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In cortical-striatal assembloids, striatal neurons (magenta) derived from individuals with Phelan-McDermid syndrome fire more frequently than neurons from controls.

Brain ‘assembloids’ capture circuit flaws in syndrome tied to autism

by  /  21 January 2021

Merging 3D clusters of neurons that mimic different brain regions models the atypical electrical activity seen in an autism-related condition.

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human and mouse cells.

Atlas pair profiles fetal gene expression, regulation in single cells

by  /  7 January 2021

A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.

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December 2020
Brain organoid with multiple stains; red and green, to indicate cells.

New method probes genes’ function in brain organoids

by  /  16 December 2020

A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.

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Global map of 17,800 human proteins.

Proteome map identifies more than 90 percent of all human proteins

by  /  9 December 2020

Researchers expand on the already enormous progress made on the Human Proteome Project

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stock image shows a color coded DNA sequence

Catalog details sex differences in gene expression, regulation

by  /  2 December 2020

Researchers expand a massive repository of data on gene activity in people to show differences between males and females.

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November 2020

Test gauges autistic children’s verbal abilities in natural settings

by  /  18 November 2020

An interactive assessment allows clinicians and researchers to evaluate an autistic child’s use of language in everyday social situations.

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A child with a young adult giving a test based on play.

Test measures autistic children’s language ability across wide age, skill range

by  /  4 November 2020

A new test can measure the language skills of autistic children of any verbal ability, at almost any age.

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