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Emerging tools and techniques that may advance autism research.

Someone in a yellow shirt stands at a kitchen counter, watching a cooking video on a small tablet computer and following along.

Standard quality-of-life screener validated for autistic adults

by  /  24 May 2022

Researchers updated the tool’s scoring system to better align with the experiences of autistic people.

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May 2022
3D rendering of a mouse brain showing axons coming from the prefrontal cortex in various colors.

New atlas maps neuronal wiring in mouse brain

by  /  3 May 2022

The ‘projectome’ charts axonal pathways between individual cells in the prefrontal cortex, a brain region implicated in autism.

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April 2022

Deep-learning tool tracks interacting animals in real time

by  /  27 April 2022

By coupling the tool — called SLEAP — with optogenetics, researchers can determine the neural circuits underlying social behaviors.

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Miniature microscope records thousands of neurons in moving mice

by  /  12 April 2022

The open-source device achieves subcellular resolution in a larger tissue volume than was possible with prior miniscopes, without impinging upon a mouse’s behavior.

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Open-source algorithm automates common marble-burying assay

by  /  1 April 2022

The machine-learning tool, which automatically counts how many marbles a mouse buries, appears to distinguish between hyperactivity and repetitive behaviors.

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March 2022

New MRI probe illuminates neuronal interactions

by  /  30 March 2022

The calcium-sensing instrument translates neuronal activity into signals that can be detected via functional magnetic resonance imaging (fMRI).

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New human neuron assays set stage for high-throughput autism drug screens

by  /  22 March 2022

The ability to conduct large-scale screening in human neurons could accelerate the discovery of autism treatments.

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Silenced X chromosome genes reawaken in new mouse model

by  /  3 March 2022

The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.

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February 2022

Probe captures neuronal conversations in people

by  /  9 February 2022

A modified version of a probe commonly used in animals detected neuronal activity across different cortical layers in three people undergoing brain surgery.

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Software automatically measures mouse's gait and posture by tracking various points on the mouse's body.

Algorithm spots subtle gait changes in autism mouse models

by  /  4 February 2022

By automatically quantifying gait and posture in videos of mice, a new machine-learning tool could accelerate research on how autism-linked mutations or drug treatments affect motor skills.

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January 2022

Neuron-specific virus overcomes barriers to brain-related gene therapy

by  /  14 January 2022

A new viral variant can deliver genes exclusively to the brain, overcoming a key hurdle in treating neurological conditions using gene therapy.

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