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Emerging tools and techniques that may advance autism research.

CRISPR tool creates long-lasting epigenome alterations

by  /  11 June 2021

A new spin on the classic CRISPR gene-editing tool can alter the genome’s chemical tags and suppress gene expression for months.

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June 2021
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Mini probe records neuronal activity in mouse brain over months

by  /  1 June 2021

A new miniature iteration of a popular probe enables researchers to record activity at thousands of sites across the mouse brain and track the activity of individual neurons over months — providing long-term recording at an unprecedented scale.

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May 2021
3D mouse rendering
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Virtual mouse helps scientists track behavior

by  /  27 May 2021

An animated mouse reenacts common behavioral experiments and can be used to train algorithms that automatically track lab animals’ movements.

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New benchmark for autism scale may help gauge therapies

by  /  18 May 2021

Researchers have defined a change in score on a popular autism rating scale that signifies a meaningful improvement in core traits. The measure could help scientists assess the effectiveness of autism treatments in clinical trials.

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Neurons in green
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New unified toolbox traces, analyzes neurons

by  /  13 May 2021

‘SNT’ helps researchers sift through microscope images to reconstruct and analyze neurons and their connections.

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April 2021
Colorful RNA in mouse brain slice
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Tissue-swelling method divulges RNA locations, sequences in cells

by  /  28 April 2021

A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.

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single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.
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Intact-cell sequencing lays bare new view of genome structure

by  /  22 April 2021

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

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By imaging spheroids in 3D, researchers can see structures called rosettes, in which immature brain cells (green) surround a cavity (pink), of a variety of shapes and sizes.
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Airy beams capture 3D structures inside spheroids

by  /  8 April 2021

An imaging approach that captures spheres of brain cells in three dimensions could illuminate processes in early brain development.

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Atlas maps distinct cell types during earliest stages of brain development

by  /  1 April 2021

A new atlas profiles gene activity early on during development in the human fetal brain.

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March 2021
Genetic sequencing on computer screen in lab setting.
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Online library details traits linked to genetic conditions

by  /  31 March 2021

An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions.

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Geometric figures in soft palette shows family group following a navigator or guide figure
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Family navigation helps reduce disparities in autism diagnosis

by  /  22 March 2021

Training community members to help families access care increases the likelihood that children from low-income and minority groups will obtain diagnostic evaluations.

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