Toolbox

Thousands of protein-protein interactions mapped in mice reveal how these networks shift across seven kinds of tissue.

Researchers put hundreds of gut bacteria strains through their paces to chart the compounds each creates — and to help others explore the flora’s potential contribution to autism.

The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.

A new technique can reveal where thousands of neurons send their axons — and measure the cells’ RNA levels for dozens of genes at the same time — in the mouse brain. It could be used to profile neural circuits underlying autism.

Thanks to a new engineered protein for optogenetics experiments, researchers can stimulate neurons with less light than usual and avoid damaging brain tissue.

Researchers say they can synchronize two new devices and control neurons across 256 freely moving animals at once to study social behaviors.

A new spin on the classic CRISPR gene-editing tool can alter the genome’s chemical tags and suppress gene expression for months.

A new miniature iteration of a popular probe enables researchers to record activity at thousands of sites across the mouse brain and track the activity of individual neurons over months — providing long-term recording at an unprecedented scale.

An animated mouse reenacts common behavioral experiments and can be used to train algorithms that automatically track lab animals’ movements.

Researchers have defined a change in score on a popular autism rating scale that signifies a meaningful improvement in core traits. The measure could help scientists assess the effectiveness of autism treatments in clinical trials.