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Spectrum: Autism Research News

Molecular mechanisms: Language neurons small in autism

by  /  13 June 2012

This article is more than five years old. Autism research — and science in general — is constantly evolving, so older articles may contain information or theories that have been reevaluated since their original publication date.

Petite cells: Pyramidal neurons, which activate brain signals in a region important for language and imitation, are smaller in autism brains (left) compared with control brains (right).

Neurons that activate signals in a brain region important for language and imitation are smaller in the brains of individuals with autism than in those of controls, according to a study published 31 March in Acta Neuropathology1.

Imaging research has also shown deficits in Broca’s area during tasks that involve imitation, suggesting that it may contain mirror neurons, which are thought to fire when an individual watches or performs an action2. Some researchers have suggested that defects in mirror neurons underlie the social deficits seen in individuals with autism. 

In the new study, researchers looked at the density, number and shape of pyramidal neurons in nine postmortem autism brains and six control brains. Pyramidal neurons activate brain signals and appear early in development.

By contrast, the new study found that the number and density of pyramidal neurons are the same in the brains of people with autism and in controls, but the neurons are about 20 percent smaller in autism brains than in control brains. The difference is also more significant among younger brains than among brains from older individuals, the study found.

Small neurons could lead to defects in connectivity with other brain regions, supporting the so-called ‘connectivity hypothesis’ of autism, the researchers say.


1: Jacot-Descombes S. et al. Acta Neuropathol. Epub ahead of print (2012) PubMed

2: Heiser M. et al. Eur. J. Neurosci. 17, 1123-1128 (2003) PubMed