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Community Newsletter: Lab collaborations, interneuron network expansion, DDX3X

by  /  3 July 2022
Many mouths making conversation, with speech bubbles in red and blue.
Illustration by Laurène Boglio

Not all Twitter debates turn contentious. Case in point: This week a troop of scientists used the platform to call for greater collaboration between labs that work with nonhuman primates and those that work with rodents or humans.

“The challenge is getting the vast majority of neuroscientists, who conduct rodent or human experiments, to acknowledge the necessity of NHP research to bridge the gap between these phylogenetic levels,” tweeted Douglas Crawford, professor of neuroscience at York University in Toronto, Canada.

That task would be easier if “NHP folks were better at articulating key areas for which NHPs are indispensable,” replied Anne Churchland, professor of neurobiology at the University of California, Los Angeles. Too many, she continued, justify NHP work just by ‘claiming mice are ‘dumb, blind and not like us.’”

“Shitting on mice is counterproductive b/c NHP is the minority…by a lot,” tweeted Cory Miller, associate professor of psychology at the University of California, San Diego, who works with marmosets and wrote that he thinks NHP work needed “better integration with the mouse community to survive.”

Such integration would only help both communities, others chimed in.

“I’ve seen a lot of mouse papers that suggest they’ve discovered something novel that’s actually been well studied in monkeys,” tweeted Michele Basso, professor of neuroscience at the University of California, Los Angeles. “Let’s work together !!”

Likewise with humans and NHPs,” Crawford commented. “Human neuroscience provides a more global view, like looking at earth from space, while NHP neurophys is like getting down to the ground where the people are and shaking hands.”

Other cross-species comparisons cropped up on Twitter in the feed of Moritz Helmstaedter, professor of neuroscience at the Max Planck Institute for Brain Research in Frankfurt, Germany, who asked “What makes us human, at the neuronal network level?” His recent finding offers one answer: a 10-fold expansion of interneuron-to-interneuron networks in the human brain compared with the mouse brain.

Helmstaeder went on to explain how he and his collaborators reached that conclusion in another 25+ tweets — earning thousands of likes, hundreds of retweets and tens of quote tweets.

Thank you for a great collaboration,” tweeted co-investigator Hanno Meyer, a neuroscientist and neurosurgeon at the Technical University Munich in Germany.

“Fascinating study of #brainevolution,” tweeted Christopher Walsh, Bullard Professor of Pediatrics and Neurology at Harvard University.

Future work into “possible pathological alterations of human cortex” should consider “alterations in interneuron-to-interneuron connectivity,” tweeted Cedric Boeckx, research professor of linguistics at the University of Barcelona in Spain.

And DDX3X, a gene linked to autism and cancer, featured in several other popular tweets. Matthew Hurles, head of human genetics at the Wellcome Sanger Institute in Hinxton, U.K., shared a thread about his new preprint that maps the functional effects of all known variants in the gene.

After introducing the variants into HAP1 cells and tracking their relative abundance over 21 days, the team grouped 3,432 variants into three categories: fast depleting, slow depleting and enriched.

The results are “highly informative” for neurodevelopmental conditions and cancer, Hurles summarized, even though they come from a cell type with minimal relevance to either condition, “suggesting that, for DDX3X, pathogenic variation is protein-intrinsic.”

“Beautiful analysis” was how Clare Turnbull, professor of translational cancer genetics at the Institute of Cancer Research in London, U.K., described it a quote tweet. “Beautifully exemplifies the power to advance variant interpretation,” she added.

“Terrific work,” wrote Veera Rajagopal, a scientist at the biotechnology company Regeneron Pharmaceuticals in New York.

Debra Silver, associate professor of molecular genetics at Duke University in Durham, North Carolina, posted about her unrelated work on the mechanisms of DDX3X mutations in mice — findings that Spectrum covered last month. “We profile translation at onset of neurogenesis highlighting importance of RNA regulation,” Silver wrote.

Great story by Debbie Silver lab!” wrote Joseph Gleeson, professor of neurosciences at the University of California, San Diego, who served as editor for the study for the journal eLife.

That’s it for this week’s Community Newsletter! If you have any suggestions for interesting social posts you saw in the autism research sphere, feel free to send an email to [email protected].

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Cite this article: https://doi.org/10.53053/KXNO9098


TAGS:   autism, community