Skip to main content

Spectrum: Autism Research News

News The latest developments in autism research.

Cognition and behavior: Maternal infection linked to anxiety

by  /  18 July 2012

This article is more than five years old. Autism research - and science in general - is constantly evolving, so older articles may contain information or theories that have been reevaluated since their original publication date.

Fear factor: Rats that learn to associate a certain sound with a foot shock freeze and emit distress calls whenever they hear that sound.

Pups born to pregnant rats with activated immune systems emit more distress calls when they receive electrical shocks than do controls, according to a study published 9 June in the Journal of Psychiatric Research1.

In the new study, researchers injected rats at day 15 of pregnancy with a molecule that mimics a virus. They then recorded the offspring’s ultrasonic vocalizations — cries inaudible to the human ear — in response to a series of tones followed by foot shocks.

Rats born to mothers whose immune systems were stimulated emit more 22-kilohertz calls than do control rats, the researchers found. Control rats normally produce these calls when exposed to predators, and the cries are associated with activity in the amygdala, a brain region involved in processing fear and emotion2.

By contrast, the immune-exposed rats emit 50-kilohertz cries — which have been linked to play and rewarding experiences — as often as controls do.

The immune-exposed rats jump just as high in response to a shock as controls do, suggesting that the shock is not more painful to them. They also freeze in anticipation of the shock, just as controls do. These results indicate that the difference is specific to the fear response as assessed by ultrasonic vocalizations.


1: Yee N. et al. J. Psychiatr. Res. Epub ahead of print (2012) PubMed

2: Parsana A.J. et al. Behav. Brain Res. 226, 77-86 (2012) PubMed