Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.

Strategies to replace or compensate for mutated copies of the TCF4 gene could lead to treatments for this profound form of autism, a new study suggests.

The chair and co-chair of the Student and Trainee Committee for the International Society for Autism Research share their advice for early-career researchers.

Drugs such as LSD act primarily on the serotonin system, which is implicated in autism — and some autistic people who experiment with psychoactive compounds report enhanced social connections, among other benefits. But researchers have more questions than answers.

This month’s newsletter also highlights deflated autism prevalence estimates from Shanghai, China.

The autism science community this week tweeted about whether underpowered studies pose ethical questions, if Spectrum 10K should restart and why autistic advocates participate in biomedical research.

After a months-long review, the United Kingdom’s Health Research Authority upheld an earlier ethics approval for the embattled autism genetics study.

Machine-learning tools are widely available and can help speed up studies in animal models of autism. Here’s how to get started with the ‘minimal viable product’ and a few pro tips.

Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.

This week’s newsletter looks at tweets about COVID-19 at last week’s INSAR meeting, an unusual enhancer regulating the autism-linked gene PTEN, and new findings from the Infant Brain Imaging Study.