This top-down view of the mouse brain is part of a new atlas that provides the most detailed 3D views to date. Researchers can use the reference to combine, analyze and share various types of mouse brain data.
The SYNGAP1 protein is located mostly at synapses, the junctions between neurons, (green) where it helps brain cells pass along chemical signals. People with a mutated copy of SYNGAP1 often have autism, as well as intellectual disability, epilepsy and an impaired gait.
A new technique called Perturb-seq makes it possible to screen for multiple autism-gene mutations (red), one by one, in living mice and to analyze their effects in individual cells.
Fifteen different drugs commonly prescribed to people with autism created unique behavioral signatures in mice.
Neurons derived from people with 22q11.2 syndrome are hyperexcitable and show calcium-signaling deficits.
Stimulation of neurons that extend from the prefrontal cortex to the amygdala (pink) causes social problems in mice.
Young zebrafish have transparent skin, which allows researchers to track the movements of glowing beads through their gut.
Gut neurons and glia (red, green) are fragile and interwoven with other cells (blue) in the colon, making them tricky to isolate.