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Society for Neuroscience 2022

SFN 2022
Geometric black-and-white brain model over a grid.

Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism

by  /  22 November 2022
The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.
SFN 2022
Light micrograph of microglia cells stained with Rio Hortega’s silver carbonate method.

Autism’s sex bias tied to glial, immune cell gene expression

by  /  22 November 2022
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
SFN 2022
Grid of nine mri scans of mouse brains.

Shared brain structure, connectivity hint at autism subgroups

by  /  21 November 2022
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
November 2022
Image of organoids modeling CDKL5 deficiency disorder.
SFN 2022

Organoids identify potential therapies, circuit flaws for autism-linked syndromes

by  /  21 November 2022

Brain cell clusters serve as drug screens and reveal connectivity differences for autism-linked conditions, two new models show.

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Still image showing activity of activity of neurons with genetic mutations in the 15q11-13 chromosomal region.
SFN 2022

Single gene insufficient to account for dup15q, Angelman traits

by  /  18 November 2022

UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.

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Marco Pagani stands in front of his research poster.
SFN 2022

Subtyping autism using fMRI: A quick take at SfN with Marco Pagani

by  /  18 November 2022

Pagani used mouse models to connect autism etiologies to brain connectivity alterations and then found similar alterations in people with idiopathic forms of the condition.

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Still image from video of zebrafish swimming in small enclosures.
SFN 2022

Zebrafish social behavior swims into mainstream

by  /  17 November 2022

New studies bolster the idea that zebrafish models can say something meaningful about social behavior in autism.

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An older woman with gray hair sits on a couch and speaks with a clinician.
SFN 2022

Brain’s memory center flags autistic adults at risk for cognitive decline

by  /  17 November 2022

Brain scans of the hippocampus reveal autistic people who are at increased risk of cognitive problems as they get older.

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Two white mice socialize.
SFN 2022

Autism genes converge on disruptions in social brain circuit

by  /  17 November 2022

The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.

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Ellen Hoffman sits in a chair and smiles.
SFN 2022

Screening zebrafish autism models: A quick take at SfN with Ellen Hoffman

by  /  16 November 2022

Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.

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A white mouse sits on a nest against a blue background.
SFN 2022

Mouse models help sniff out olfactory differences in autism

by  /  16 November 2022

A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.

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Tuan Chao speaks about her research.
SFN 2022

Tying PPFIA3 to autism: A quick take at SfN with Tuan Chao and Maimuna Paul

by  /  15 November 2022

Work in fruit flies has helped Paul decode a neurodevelopmental syndrome in children caused by rare de novo variants in the gene PPFIA3.

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White laboratory mice isolated on orange luminous glass surface.
SFN 2022

New evidence hints at mechanisms for ‘fever effect’ in autism

by  /  15 November 2022

The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.

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