Genes linked to autism in sequencing studies tend be located in long stretches of DNA that are duplicated or missing in some people with developmental conditions.
Spectrum: Autism Research News
American Society of Human Genetics 2018
Some mutations that contribute to autism and arise spontaneously may be mistaken for inherited mutations.
The largest-ever set of sequences from people with developmental delay has revealed 43 new genetic diagnoses.
Clusters of brain cells — so-called 'mini-brains' grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.
The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.