Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.
A new technique for masking portions of raw genomic data increases shareability without sacrificing privacy.
Two types of neurons process social information, a new mouse study suggests, but only one is disrupted in mice missing the autism-linked gene FMR1.
Genetic sequences from nearly 53,000 people with autism, developmental delay or intellectual disability reveal strong ties to 98 genes.
Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.
Mutations in a top autism gene called SYNGAP1 slow the rate at which zebrafish digest food and pass waste, and may also disrupt gut function in people.
Mice with mutations in the autism-linked gene SYNGAP1 have trouble sensing touch, which may stem in part from brain-circuit alterations and dulled alertness.
Autistic people’s ability to understand another person’s thinking does not diminish with age, as it does for non-autistic people.
Prisons are often ill-equipped to handle autistic inmates, who are at risk for mental health problems and abuse.
Autistic people vary widely in how they describe their quality of life. Anxiety and depression may account for that range more than traits of autism do.