Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit’s activity corrects the learning deficit.
Spectrum: Autism Research News
Autistic children with sensory issues show more intense physiological reactions to unpleasant sounds and other sensations than their non-autistic peers do, a new study shows.
Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.
People with fragile X syndrome in Colombia are diagnosed at age 27, on average, according to the first study to assess diagnosis in the country. By comparison, the average age of fragile X diagnosis in the United States is younger than 4.
Spectrum spoke with three Black scientists about why they got into autism research, what keeps them excited about their work and how the field could become more diverse.
A glowing protein tracks serotonin levels and location in the brains of living mice and could yield clues to the neurotransmitter’s role in autism.
Mice missing a copy of MAGEL2 have trouble discerning between a familiar mouse and an unfamiliar one; treating them with the social hormone vasopressin reverses this deficit.
Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.
People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.
Deleting the autism-linked gene CNTNAP2 from mice leads to distinct cellular and electrical changes in the cerebellum, according to two unpublished studies presented virtually today at the 2021 Society for Neuroscience Global Connectome.